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Cycloxan (Cyclophosphamide)

Cycloxan remains one of the most successful and widely utilized antineoplastic drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation (BMT). It was initially synthesized to selectively target cancer cells, although the hypothesized mechanism of tumor specificity (activation by cancer cell phosphamidases) transpired to be irrelevant to its activity. Nevertheless, Cycloxan's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties. Differential cellular expression of aldehyde dehydrogenase has an effect on the anticancer therapeutic index and immunosuppressive properties of Cycloxan. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of Cycloxan in cancer and autoimmune disorders. We also discuss the development of high-dose Cycloxan for BMT and the treatment of autoimmune diseases.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

Similar Products:
Eselan, Mutabon, Mykrox, Klarimax, Baclofeno, Clindacin, Dalsan, Sigmaxin, Lopressor, Betaren, Tadalafil, Alzam, Simox, Milorin, Kirim, Nitrest, Gastral, Lomex, Trevilor, Tadalis, Levomac, Omnicef, Prostol, Sofovir, Esomac, Texidep,

Cycloxan is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cycloxan is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cycloxan is also used for some kinds of kidney disease.

Cycloxan interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by Cycloxan, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with Cycloxan, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule
  • Powder for Solution
  • Tablet

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Finite element method simulation of the molding process for thermal nano-imprint lithography. Superior mesenteric arterial flow, arterial pressure, and heart rate were recorded, and plasma arginine-vasopressin (AVP) concentration was measured, during intravenous infusions of AVP (0.1-8.1 mU X kg-1 X min-1) in conscious unrestrained cats under two experimental situations--when autonomic function remained intact and, on other days, when it had been impaired by pretreatment of the animals with the ganglionic blocking agent pentolinium tartrate (2.5 mg X kg-1 and 0.125 mg X kg-1 X min-1).

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One method of draping for total knee replacement (TKR) surgery involves cleaning the operative leg with antiseptic wash then covering the un-prepped foot with a sterile stockinette to sequester the foot from the sterile field. Food, global environmental change and health: EcoHealth to the rescue? The technique of femtosecond pulse shaping is used for further improvement of accuracy and stability against noise. A semiparametric missing-data-induced intensity method for missing covariate data in individually matched case-control studies. Chondromyxoid fibroma constitutes a rare benign tumor of the bones, which has a potential of regional enlargement towards the local tissues.

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To examine whether the information in the medical records of soldiers can be used to identify those suffering from anxiety, affective or somatoform disorder. Inhibition by diethylcarbamazine of acetylcholine-induced endothelium-dependent relaxation of rabbit aorta: are leukotrienes involved?

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The histological and histochemical profile of foci and tumors matched closely. The place of clinical modification of transmitter system is discussed, but no conclusions or recommendations can be made at this early stage. It was hypothesised that the significant difference in spray deposition with equal injury rates can be attributed to enhanced bioactivity of the nanoemulsion formulations. The Spanish translation and evaluation of a quality-of-life questionnaire in patients with chronic obstructive pulmonary disease

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Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin. Cathepsin B and cathepsin K can be further evaluated as biomarkers in identifying high-risk individuals for AMI.

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In this study, using a behavioral and biochemical approach, we investigated involvement of oxidative stress mechanisms in sleep deprivation-induced anxiety-like behavior of rats and the protective role of treadmill exercise in this process. Unravelling the origin of beta cells during pancreatic regeneration could help restore a functional beta-cell mass in diabetes patients. In this video, the full process of an animal model of heart failure creation followed by gene transfer is presented using a swine model. The degree of inhibition is also comparable to the inhibition of CFUS mobilization.

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To determine the effect of the inhibitors of energy metabolism, 2-deoxyglucose (2DG) and sodium azide, on radiation-induced apoptosis. The PAHs, in particular Carc-PAHs, were negatively correlated to the tested heavy metals. To investigate the effects of essential oil (EO) from rhizomes of Ligusticum chuanxiong Hort. All patients formed antibodies against contaminants in the concentrated crude interferon and the partially purified interferon preparation which had been used for treatment. Importance of GluA1 subunit-containing AMPA glutamate receptors for morphine state-dependency.

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Numerical simulation analyzed the reconstructed image quality and diffraction efficiency versus degree of phase compression and showed that phase compression resulted in little image degradation or power loss. These data suggest that osmium tetraoxide postfixation can be used for the detection of low molecular weight peptides such as LH-RH, somatostatin, and ACTH-like-peptides not only in the median eminence but also in the hypothalamus. Recently, various progresses have been made in the treatment of the genitourinary malignant tumors. Hydrolysis of triglycerides by pancreatic lipase and formation of free fatty acids that induce inflammatory changes are postulated to account for the development of HTGP, yet the exact pathophysiology remains unclear.

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The Cochrane Dementia Group trial register, ALOIS, searched for the last time on 3 May 2011. Error decomposition and estimation of inherent optical properties.

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Coconut (Cocos nucifera L.) water is a refreshing tropical drink whose international market has recently been growing. Cell confinement controls centrosome positioning and lumen initiation during epithelial morphogenesis.

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Preparation of poly(gamma-L-glutamate) from cell wall component. With this approach, intrinsic enzymatic activity of a diseased tissue activates the formulations. iPSCs were cultured in vitro in a 3D scaffold in chondrocyte differentiation medium. A point mutation of a small globular protein, the C-terminal domain of L9 destabilizes the protein and leads to observable cold-denaturation at temperatures above zero. The physiological substrate of DT-diaphorase is unknown, and it is possible that the protein derived from the alternatively spliced NQO1 mRNA could have enzyme activity with an appropriate substrate.

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Cloud point extraction of copper, lead, cadmium, and iron using 2,6-diamino-4-phenyl-1,3,5-triazine and nonionic surfactant, and their flame atomic absorption spectrometric determination in water and canned food samples. The abilities of normal pastel and sapphire mink to produce interferon when inoculated with either Newcastle disease virus or a synthetic polyribonucleotide, poly (I):poly (C), were identical, even to the production of a novel, acid-labile interferon. Long-term follow-up of children treated for cancer: why is it necessary, by whom, where and how?

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Our systematic analysis of autophagic and endolysosomal activities outperformed conventional autophagy assays and highlights the complexity of drug influence on autophagy. Kidney donation after circulatory death in a country with a high number of brain dead donors: 10-year experience in Belgium. A simple frequency-domain technique for measuring polarization-mode dispersion in single-mode fibers with random mode coupling is used to give what is to my knowledge the first direct experimental demonstration of the transition of the dispersion from a linear length dependence to a square-root-of-length dependence.

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Pulse oximetry--clinical implications and recent technical developments. Infrared analysis did not indicate osteomalacia in the bone tissue of LPA(1)-invalidated mice. Recanalization was attempted but guidewires could not be passed across the site ofocclusion.

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The programme was designed to help practitioners work imaginatively with the care decisions they are required to make with patients and their loved ones. Working collaboratively across disciplines is essential in order to better understand and challenge an important human and animal health problem: antimicrobial resistance. To explore internal consistency and correlations between perceived ability, performance and perceived importance in a preliminary selection of self-reported items representing the activity/participation component of the International Classification of Functioning, Disability and Health (ICF).

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Randomized, double-blind, placebo-controlled 3-month parallel treatment arms with flexible dosage and with the length of clinical contact randomized within each treatment group. Using this approach, we demonstrated reduced serum levels of bone resorption markers in patients treated with SRL after kidney transplantation compared to a CI-based regimen.

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Two patients responded rapidly to treatment with soft contact lenses. These findings represent initial steps that may help in improving the clinical utilization of topical Pc 4-PDT. The amount of T- and B-lymphocytes and interleukin-2 production was estimated under various conditions during the priming procedure, and those optimal for generation of a high number of antigen-specific B-lymphocytes determined. Furthermore, the eye region was attended to more pronouncedly when fearful or neutral faces were shown whereas more attention was directed toward the mouth of happy facial expressions.

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Tubulin from Trypanosoma brucei was characterized by Western blotting using well defined monoclonal antibodies reacting with alpha- or beta-tubulin and a new monoclonal antibody, 1B41, raised against a microtubule-enriched fraction of T. The herbal medicine rikkunshito exhibits strong and differential adsorption properties for bile salts.

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Epitope-specific amplification of immunosuppression induced by monoclonal suppressor-T-cell products. A special electrode design reduces melting of the electrode tips, and thus the arc provides the necessary brightness for periods of the order of hours. The aim of this review is to analyze the morphological aspects of the vascular component in airway remodelling in asthma, as well as its pharmacological modulation.

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Our results in a Japanese population with lower intakes and different major food sources of zinc and heme iron in comparison with those of Western populations suggest that zinc and heme iron intakes are not associated with colorectal cancer. We prospectively evaluated the plan and surgery in 60 patients treated with 66 TKAs performed with patient-specific instrumentation and recorded any changes.

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Another aspect of B7-H3 that so far has received little interest is its role in non-immunological systems. Quantification of protein immobilization on substrates for cellular microarray applications. More attention should be paid to parents with childhood maltreatment experiences, low social support and less positive parent-to-child interaction attitudes. We showed that feeding DWV to larvae causes wing deformity in adult bees in the absence of varroa mites and decreases survival rates of adult bees relative to bees not fed DWV. A fatal case of meningoencephalitis caused by Bacillus cereus, an uncommon but potential pathogen, resistant to most beta-lactam antibiotics, is described in a 28-day old premature neonate.

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Cepharanthin enhanced LPS-induced HDC activity in normal mice spleens and also enhanced it in genetically T cell-deficient nude mice spleens and T and B cell-deficient scid mice spleens. Phase Three involved the testing of the EDPA for interrater reliability, which resulted in highly significant intraclass correlations.

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Alteration of brain stem auditory evoked responses following cardio-respiratory arrest and resuscitation. A statistically significant decrease in plasma prekallikrein was observed after the high-osmolality contrast medium, which is a sign of the activation of the kallikrein-kinin system and an indicator of the activation of the intrinsic coagulation.

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According to the sequence of human PLCG1 splicing variant, specific primers for rat PLC-gamma1 were designed and synthesized. NO can react with Hb in at least 3 ways: 1) formation of Hb(II)NO, 2) formation of methemoglobin, and 3) formation of S-nitrosohemoglobin, through nitrosylation of the beta93 Cys residue. The potential distribution of the RP, however, is different from the stimulus-preceding negativity (SPN), a pointing to a different electrophysiological source. On the basis of a narrowing of the dispersion of the immune components to the end of the cure compared with the beginning of the cure is concluded that the changes of defensive components to the blood which are to be observed in different initial values are not only based on the endogenic rhythmicity but partly also on the effects of the spa therapy. Challenge to understand the neurobiology of obsessive-compulsive disorder

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Kinetics of adaptation of protein synthesis and its effect on enzyme content. Because the PFE0565w protein is present in salivary gland sporozoites, it could be a novel candidate for a pre-erythrocytic stage vaccine. Depending on the phase of ice that forms around the nanodroplets and on the composition of the oil mixture, nanoinclusions can be observed inside oil nanodroplets, independent of surfactant type. Differences between the groups were also found on specific quantitative and qualitative aspects of symbolic play. Biological and physico-chemical tests are generally of limited value but their application may be useful in certain circumstances.

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We now show that Fbxw7 regulates the proliferation and differentiation of keratinocytes by mediating the degradation of c-Myc and Notch proteins. Measurement of interferon effects on murine leukemia virus (MuLV)-infected cells. Evidence on the utility of hemodynamic monitorization in the critical patient Optimizing the mobile phase for separation of phosphatidylcholine and phosphatidylethanolamine in soybean lecithin. A comparative study of the effects of hemodilution with dextran and fluorocarbon emulsion on the changes in blood viscosity and collateral flow during myocardial ischemia

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Short pulses of ACh stimulation sharply and reversibly reduced input resistance both in control and test periods. Tumour and corresponding normal tissues were analysed for CASC2a mRNA expression by real-time RT-PCR and mutation status by PCR-based approaches. It hydralazine drug profile of losartan turns out that the mixtures exhibit two glass transitions in a wide concentration range although being fully miscible on a macroscopic scale.

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Percutaneous revascularization of reoccluded meso-Rex shunts in extrahepatic portal vein obstruction. Trichotillomania and co-morbid psychiatric disorders in a 10-year-old omebeta 20 beta pharmaceutical boy. Increases in collagen content in the myocardium of APA patients may be reversed by adrenalectomy. A theoretical model for description of reabsorption in a thin layer is developed.

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Effect of Mycobacterium smegmatis vaccine on the level of nitric oxide produced by peritoneal macrophages in mice The validity of this model has been demonstrated wykres naproxen and alcohol with a remodeling simulation using a two-dimensional trabecular model.

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TNF-blocker therapy persistence is low among PSO patients in this health plan. Laboratory observations on Toxorhynchites splendens Wiedemann in Thailand. In contrast to previous studies, these findings show no ziprax 100 dry syrup powder association between use of a regional transport service and time of the month. A novel molecular probe sensing polynuclear hydrolyzed aluminum by chelation-enhanced fluorescence. In human melanoma cells, the integrin alphavbeta3 is involved in transendothelial migration and its expression correlates with metastasis.

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Multidisciplinary tracheostomy teams have been implemented in acute hospitals over the dasabuvir dose past 10 years. In Cx36-deficient mice and controls we occluded the distal middle cerebral artery.

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The initial vascular response to aneurysm-initiating hemodynamic insult includes localized generico augmentin antibiotico pediatrico matrix degradation and cell apoptosis. Five murine hybridoma lines that produce monoclonal antibodies against Epstein-Barr virus membrane antigen (MA) were established.