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Calan (Verapamil)
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Verapamil

Although the characteristics of interaction were not clear, GLZ seemed to mainly affect HSA binding of nifedipine rather than AAG binding, while GLZ seemed to affect both AAG- and HSA-bindings of Calan and diltiazem resulting in a serum binding displacement.

Other names for this medication:
Verapamil, Calan, Calaptin, Isoptin, Verelan,

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Calan is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Calan is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, Calan relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Tablet, Extended Release
  • Capsule, Extended Release

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Presented herein are the techniques and results of such clinical experience. To establish a detailed technical procedure for studying the anatomical correlates of chronic cerebrospinal venous insufficiency in cadavers of multiple sclerosis and control subjects, and to present our findings of the normal anatomic venous structures, with reference to previous descriptions from the literature. Moreover, dehydroepiandrosterone inhibited chemokines, including CCL11/eotaxin-1 and CCL24/eotaxin-2, and Th2-associated cytokine levels in bronchoalveolar lavage fluid. The analysis shows the potential for an early epidemic peak occurring in October/November in the Northern hemisphere, likely before large-scale vaccination campaigns could be carried out.

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The analysis included consecutive adult patients being surgically treated for degenerative conditions of the lumbar spine, with either an MIS or open approach for two-level instrumented lumbar fusion. We hypothesized that the general inflammation observed in the wall of large, asymptomatic abdominal aortic aneurysms (AAAs) could be detected in vivo by 18-fluorodeoxglucose (FDG) positron-emission tomography (PET) and, if so, that this method could be used to study if active inflammation is an early pathogenetic finding in small AAAs detected by screening. The significant differences between the patients in the two groups seem to support the hypothesis that hallucinatory disorder may be considered as being a separate nosographic entity, in which the clinical picture is dominated by the experience of auditory verbal hallucinations.

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Such change could lead to impairment of quality of life and well-being as well as to increasing the risk of important healthcare-associated infections such as nosocomial pneumonia. Characteristics of insulin receptors and insulin action in human hepatoma cell line J-5. Three patients with medial frontal lobe lesions primarily involving the ACC performed tasks on motivational decision making, emotional facial expression recognition, and social cognition, including theory of mind (ToM).

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MreA functions in the global regulation of methanogenic pathways in Methanosarcina acetivorans. Separability of tight and roaming pathways to molecular decomposition. Concordantly, CRF, AVP, and OT contents in the median eminence decreased compared to controls. One fundamental challenge in fine-mapping associations to functional alleles is the enormous sequence diversity and broad linkage disequilibrium of the MHC, both of which hamper the cost-effective interrogation in large patient samples and the identification of causal variants.

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The management of CF-related haemoptysis, the impact of an ageing CF population and the incidence of thromboembolic disease in CF are discussed. The cells undergo a final round of DNA replication, double their genome to 4 n and become arrested in the G2-phase of the cell cycle. In vitro comparison of a disposable flexible ureteroscope and conventional flexible ureteroscopes. In 1961, Crick, Barnett, Brenner, and Watts-Tobin (Crick et al., 1961) designed an elegant experimental strategy to determine the nature of the genetic code. Here we report the development an in vitro assembly system for the well characterized dsDNA phage Phi29 which results in the co-assembly of connector with capsid and scaffolding proteins to form procapsid-like particles (PLPs).

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Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans. Identification and fine mapping of qCTH4, a quantitative trait loci controlling the chlorophyll content from tillering to heading in rice (Oryza sativa L.). To address the issue, we developed a unique three-step assay of high proliferative potential (HPP) precursors. However, IgG4-related TIN without AIP or lacrimal and/or salivary gland lesions has not been well recognized. Adenosine changed the expression of virulence factors in EPEC, inhibiting the expression of the bundle-forming pilus (BFP) and enhancing expression of the EPEC secreted proteins (Esps).

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sensitivity to specific proteases) and the environment provided by the production host (e.g. Lyophilized recombinant Deinococcus cells retained viability and PhoN activity and could efficiently precipitate uranium from aqueous solutions for up to six months of storage at room temperature. A partial thrips transcriptome was generated using 454-Titanium sequencing of cDNA generated from F. Sequence variation that results in changes in DNA conformation and vimentin binding to the promoter may be relevant to ALOX15 gene regulation.

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Surgical safety checklist: improved patient safety through effective teamwork. The effect of CPH-86 on lymphocytes in conjunction with mitogen is nonlethal, evident during the early but not the late phases of proliferation, and associated with early increases in cyclic AMP levels. The prevalence of hepatitis B surface antigen in the Gampaha district. A subset of Wa RFs, however, and the anti-CMV antibody do share several idiotypes on the VHIa and VKIIIb polypeptides.

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Spontaneously elevated nociceptive threshold levels were markedly diminished after Naloxone injections in 4 patients with congenital insensitivity to pain. Triggering of the Bergman cyclization by photochemical ring contraction. We present details of a simple method, incorporating first-order perturbation theory, to analyze the birefringence exhibited by elliptical-core fibers by using an equivalent rectangular-core waveguide. In the diabetic group mean smooth muscle area significantly decreased but was restored after combined tempol and insulin. The chief complains were pain around cervical part and shoulder blades, some accompanied with decrease of motor power and sensation in upper or lower limbs.

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The existence of precursors for TI and TD alpha 1 leads to 3 dextran antigens in BALB/c mice was demonstrated. Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers. However, to date, a head-to-head comparison of competing measures for whiplash patients has not been performed. The mortality, length of hospitalization, and costs associated with invasive fungal infections (IFIs) in hospitalized patients were studied. The regulatory effect of complement on TLR-induced cytokine production in vivo was mediated by the anaphylatoxin receptors C5aR and C3aR.

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Flaxseed does not enhance the estrogenic effect of low-dose estrogen therapy on markers of uterine health in ovariectomized rats. Correlating protein function and stability through the analysis of single amino acid substitutions. The monoclonal antibody 4F2 has a distribution similar to OKT9, but it is structurally distinct, and is also present on monocytes.

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Exogenous attention to facial vs non-facial emotional visual stimuli. Expression of CD147 in groups 3 and 4 was significantly higher than in groups 1 and 2. Within this clade, Pronephrium, and Christella were revealed to be polyphyletic, but several Asian-endemic segregates, such as Glaphyropteridopsis, Mesopteris, and Pseudocyclosorus were strongly supported as monophyletic. Myristylation-deficient HERV-K(CON) Gag localized to nuclei, suggesting cryptic nuclear trafficking of HERV-K Gag. Expression of E-cadherin in canine anal sac gland carcinoma and its association with survival.

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The diagnosis of intestinal malrotation is based on an upper gastrointestinal contrast series (UGI), which is considered the imaging reference standard. However, tubular cell apoptosis was prominent, and caspase 3 activity was positively correlated with renal dysfunction. There is strong evidence that a neoadjuvant combination of radiation and chemotherapy improves resection and survival rates compared with surgery alone, but definitive proof is not currently available. To examine debris size generated during in vitro plaque ablation by laser energy and estimate the risk of peripheral embolization following laser angioplasty. Multisensory convergence and integration in the neostriatum and globus pallidus of the rat.

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Dexamethasone treatment interferes with the pharmacokinetics of ivermectin in young cattle. Evidence for the presence of dipeptidyl carboxypeptidase and its inhibitors in inflammatory synovial fluids. The expression of these genes was not affected in head kidney leukocytes (HKLs) infected with VHSV, leading us to evaluate the potential cytotoxic activity of RTS11 and HKLs. We designed this study to observe the DM prevalence, insulin resistance, beta cell reserve and the interaction of these parameters in the first degree relatives of Type 2 diabetic patients in Turkish population. The conclusion is made about domination of diencephalic influences over the telencephalic one in the studied patients.

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Basic x-ray picture of the large intestine using double contrast method Chemical characterization of a family of brain lipids that induce sleep.

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The endothelium is the primary fluid barrier of the vasculature and ultimately the effects of dengue virus infection that cause capillary leakage impact endothelial cell (EC) barrier functions. Results suggest that arachidonate 5-lipoxygenase products (such as leukotriene B4, C4, D4 or E4) are involved in the pathophysiology of PIB but their contribution may be small. The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence. Prevalence of functional dyspepsia and its subgroups in patients with eating disorders. In this study, the prevalence of hypopituitarism during long-term follow-up after TBI was low.

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The so-called Garcia Gonzalez reaction had been almost forgotten for 50 years, until the emergence of new water tolerant catalysts having Lewis acid behavior. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. The conjugate displayed very high target specificity in vitro and strongly inhibited Tat mediated transactivation of HIV-1 LTR transcription in a cell culture system. Aortic anomalies and variations in aortic branches are caused by embryonic malformations and are mostly described in association with congenital heart lesions.

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A novel in-gel assay and an improved kinetic assay for determining in vitro sulfite reductase activity in plants. X-ray crystal structures of Phanerochaete chrysosporium Laminarinase 16A in complex with products from lichenin and laminarin hydrolysis. Involvement of cytokines in immunological reactions (TH1 and TH2 subset, IgE response, lymphokine activated killer, cytotoxic T lymphocyte...) and in hematopoiesis have also been studied with this approach. Genotype and allele frequencies were compared between PsA cases and controls using the Armitage test for trend.

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In this retrospective review, those patients who had a positive history of tobacco use at the time of injury and those with risk factors for atherosclerosis had a significantly increased risk of flap complications. Anionic phospholipids differentially regulate the epithelial sodium channel (ENaC) by interacting with alpha, beta, and gamma ENaC subunits. Complete resolution of SVCS symptoms occurred within 24 hr and moderate superior vena cava restenosis was successfully dilated 8 months later.

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Further tunability on the Fano resonances is gained by changing the size of the inner dielectric core, hence changing the moment of the void plasmon modes and consequently the resonance frequency. The objective of this work was to assess the risk of hematologic dyscrasias in a sample of clozapine-treated patients in a 5-year period. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.

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Radioimmunoassay of brain tissue detected GnRH immunoreactivity only when the lamprey GnRH-I antibody was used. Risk factors for postoperative pancreatic fistulization subsequent to enucleation. Furthermore, we showed that the CaRad3 protein purified from yeasts was N-glycosylated, and that this protein complemented the defects in both the NER pathway and transcription.

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Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Mechanisms other than intraneuronal release and serotonin depletion appear to mediate PCA-induced hypothermia. PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.

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However, whereas no difference between the differently pretreated groups was observed following phosphate-buffered saline administration into the nucleus accumbens, a potentiation of the locomotor response to a challenge dose of amphetamine into the nucleus accumbens was observed which was dependent on the dose of amphetamine pretreatment into the ventral tegmental area. Besides under standard assay conditions, aminoacylation reactions were studied in the presence of pyrophosphatase or elongation factor Tu-GTP complex, under addition of both these proteins, in presence of these two additional proteins and spermine at high and low magnesium concentrations, and under special conditions that favor misacylations.

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New therapies of beta-thalassemia are still being developed, both supportive and curative in nature. Colons filled fully with normal saline can surely give acoustic access to the bilateral ureters and extrahepatic bile duct so as to determine the nature of obstruction of these structures when conventional transabdominal ultrasound fails. Derivative discontinuity, bandgap and lowest unoccupied molecular orbital in density functional theory. We investigated spatiotemporal characteristics of motion mechanisms using a new type of motion aftereffect (MAE) we found.

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The disease most commonly involves subcutaneous and muscle tissues, followed by the eye and brain. Reasonable correspondence between theoretical calculations and human observer performance was achieved for all imaging tasks over the broad range of experimental conditions and acquisition schemes.

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Predicting preferences for sex acts: which traits matter most, and why? The soundness of the our approximations were tested with such measures as the fraction of the open state at time t, Popen (t), and frequencies of the number of openings per run. The time-course of lexical and structural processes in sentence comprehension. Relation of the degree of exposure to dust in the atmosphere and damage to the organs of the respiratory system in foundryworkers Labeled axons were first detected in the segment of optic nerve lying distal to the crush site 1 week after injury and had extended as far as 2.3 mm beyond the crush site by 60 days postinjury, growing at a rate similar to that diclofenac ec 50 mg bijsluiter at which the collateral branches of developing ganglion cell axons extend into their targets.

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Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. The results of this study provide empirical evidence on the efficacy of cultural clarithromycin side effects tiredness in pregnancy targeting for minority immigrants.